Casadevall Lab
Publications
Publications
SELECTED RECENT PUBLICATIONS
- Wear MP, Kim D, Roy R, Zhang S, Casadevall A. (2025 ) Unexpected variability in laboratory and clinical assays used to quantify Cryptococcus neoformans polysaccharide. J Infect Dis. Oct 24:jiaf540. https://pubmed.ncbi.nlm.nih.gov/41130592
- Grossman NT, Fan Y, Zimin AV, Wear MP, Jedlicka A, Dziedzic A, Liporagi-Lopes LC, Timp W, Casadevall A. (2025) Three annotated chromosome-level de novo genome assemblies of Lomentospora prolificans provide evidence for a chromosomal translocation event. G3 (Bethesda). 15(6):jkaf091. https://pubmed.ncbi.nlm.nih.gov/40273388
- Cordero RJB, de Groh KK, Dragotakes Q, Singla S, Maurer C, Trunek A, Chiu A, Hwang J, Crowell S, Benyo T, Thon SM, Rothschild LJ, Dhinojwala A, Casadevall A. (2025) Radiation protection and structural stability of fungal melanin polylactic acid biocomposites in low Earth orbit. Proc Natl Acad Sci U S A. 122(18):e2427118122. https://pubmed.ncbi.nlm.nih.gov/40294260
- Smith DFQ, Bergman A, Casadevall A. (2025) The dynamics of Cryptococcus neoformans infection in Galleria mellonella. mSphere. 10(6):e0019025. https://pubmed.ncbi.nlm.nih.gov/40377324
- Rodrigues Dos Santos Junior S, Stempinski PR, de Araujo MV, Rojas K, Gerbig GR, Liporagi Lopes LC, Smith DFQ, Wear MP, Casadevall A. (2025) Cryptococcus neoformans serotype A virulence and pathogenicity are capsular glucuronoxylomannan (GXM) motif composition dependent. mBio. e0264625. https://pubmed.ncbi.nlm.nih.gov/41020608
- Camacho E, Dong Y, Chrissian C, Cordero RJB, Saraiva RG, Anglero-Rodriguez Y, Smith DFQ, Jacobs E, Hartshorn I, Patiño-Medina JA, DePasquale M, Dziedzic A, Jedlicka A, Smith B, Mlambo G, Tripathi A, Broderick NA, Stark RE, Dimopoulos G, Casadevall A. (2025) Dietary L-3,4-dihydroxyphenylalanine (L-DOPA) augments cuticular melanization in Anopheles mosquitos reducing their lifespan and malaria burden. Nat Commun. 16(1):8011. https://pubmed.ncbi.nlm.nih.gov/40866335
- Jacobs E, Dragotakes Q, Kulkarni M, Kuhn K, Shen A, Dziedzic A, Jedlicka A, Hardwick JM, Casadevall A. (2025) A method for authenticating the fidelity of Cryptococcus neoformans knockout collections. Microbiol Spectr. 13(10):e0050125. https://pubmed.ncbi.nlm.nih.gov/40874741
- Liporagi-Lopes LC, Chrissian C, Camacho E, Kacirani A, Stark RE, Casadevall A (2025) Lomentospora prolificans synthesizes several types of melanin. mSphere. e0096324. https://pubmed.ncbi.nlm.nih.gov/40172218
- Stempinski PR, Ramos Irizarry P, McConnell SA, Liporagi Lopes LC, Rodrigues Dos Santos Júnior S, Wear MP, Casadevall A (2025) A Cryptococcus neoformans polysaccharide conjugate vaccine made with filtered polysaccharide elicits protective immunity in mice. Fungal Biol. 129(2):101544. https://pubmed.ncbi.nlm.nih.gov/40023532
- Jimenez IA, Stempinski PR, Dragotakes Q, Greengo SD, Sanchez Ramirez L and Casadevall A (2024). The buoyancy of cryptococcal cells and its implications for transport and persistence of Cryptococcus in aqueous environments. mSphere. 9(12):e0084824
https://pubmed.ncbi.nlm.nih.gov/39601568 - Baker RP, Liu AZ and Casadevall A (2024). Cell wall melanin impedes growth of the Cryptococcus neoformans polysaccharide capsule by sequestering calcium. Proc Natl Acad Sci U S A. 121(38):e2412534121
https://pubmed.ncbi.nlm.nih.gov/39259590 - Stempinski PR, Greengo SD and Casadevall A (2024). Growth on Douglas fir media facilitates Cryptococcus virulence factor production and enhances fungal survival against environmental and immune stressors. Med Mycol. 62(7):myae068
https://pubmed.ncbi.nlm.nih.gov/38982313 - Sanchez Ramirez L, Dragotakes Q and Casadevall A (2024). A food color-based colorimetric assay for Cryptococcus neoformans laccase activity. Microbiol Spectr. 12(8):e0044224
https://pubmed.ncbi.nlm.nih.gov/38869282 - Baker RP, Schachter M, Phillips S, Kandiah S, Farrque M, Casadevall A and Kandiah PA (2024). Host and fungal factors both contribute to cryptococcosis-associated hyperammonemia (cryptammonia). Microbiol Spectr. 12(7):e0390223
https://pubmed.ncbi.nlm.nih.gov/38842310 - Crawford CJ, Liporagi-Lopes L, Coelho C, Santos Junior SR, Moraes Nicola A, Wear MP, Vij R, Oscarson S and Casadevall A (2024). Semisynthetic Glycoconjugate Vaccine Candidates against Cryptococcus neoformans. ACS Infect Dis. 10(6):2089-2100.
https://pubmed.ncbi.nlm.nih.gov/38819951 - McConnell SA and Casadevall A (2024). Immunoglobulin constant regions provide stabilization to the paratope and enforce epitope specificity. J Biol Chem. 300(6):107397.
https://pubmed.ncbi.nlm.nih.gov/38763332 - Wear MP, McConnell SA, Greengo SD, Lopes LL and Casadevall A (2024). Methods of Cryptococcal Polysaccharide Analysis Using ELISA. Methods Mol Biol. 2775:239-255.
https://pubmed.ncbi.nlm.nih.gov/38758322 - Dragotakes Q and Casadevall A (2024). Estimating the size of fields in biomedical sciences. mSystems. 9(1):e0065223.
https://pubmed.ncbi.nlm.nih.gov/38055643 - Crawford CJ, Guazzelli L, McConnell SA, McCabe O, d'Errico C, Greengo SD, Wear MP, Jedlicka AE, Casadevall A and Oscarson S (2024). Synthetic Glycans Reveal Determinants of Antibody Functional Efficacy against a Fungal Pathogen. ACS Infect Dis. 10(2):475-488.
https://pubmed.ncbi.nlm.nih.gov/37856427 - Smith DFQ and Casadevall A (2023). Disaster mycology. Biomedica. 43(Sp. 1):267-277.
https://pubmed.ncbi.nlm.nih.gov/37721902 - McConnell SA, Sachithanandham J, Mudrak NJ, Zhu X, Farhang PA, Cordero RJB, Wear MP, Shapiro JR, Park HS, Klein SL, Tobian AAR, Bloch EM, Sullivan DJ, Pekosz A and Casadevall A (2023). Spike-protein proteolytic antibodies in COVID-19 convalescent plasma contribute to SARS-CoV-2 neutralization. Cell Chem Biol. 30(7):726-738.e4.
https://pubmed.ncbi.nlm.nih.gov/37354908 - Jacobs E, Chrissian C, Rankin-Turner S, Wear M, Camacho E, Broderick NA, McMeniman CJ, Stark RE and Casadevall A (2023). Cuticular profiling of insecticide resistant Aedes aegypti. Sci Rep. 13(1):10154.
https://pubmed.ncbi.nlm.nih.gov/37349387 - Cordero RJB, Mattoon ER, Ramos Z, and Casadevall A (2023). The hypothermic nature of fungi. Proc Natl Acad Sci U S A. 120(19):e2221996120.
https://pubmed.ncbi.nlm.nih.gov/37130151 - Baker RP and Casadevall A (2023). Reciprocal modulation of ammonia and melanin production has implications for cryptococcal virulence. Nat Commun. 14(1):849.
https://pubmed.ncbi.nlm.nih.gov/36792633 - Focosi D, Quiroga R, McConnell S, Johnson MC and Casadevall A (2023). Convergent Evolution in SARS-CoV-2 Spike Creates a Variant Soup from Which New COVID-19 Waves Emerge. Int J Mol Sci. 24(3):2264.
https://pubmed.ncbi.nlm.nih.gov/36768588 - Sephton-Clark P, McConnell SA, Grossman N, Baker RP, Dragotakes Q, Fan Y, Fu MS, Gerbig G, Greengo S, Hardwick JM, Kulkarni M, Levitz SM, Nosanchuk JD, Shoham S, Smith DFQ, Stempinski P, Timp W, Wear MP, Cuomo CA and Casadevall A (2023). Similar evolutionary trajectories in an environmental Cryptococcus neoformans isolate after human and murine infection. Proc Natl Acad Sci U S A. 120(2):e2217111120.
https://pubmed.ncbi.nlm.nih.gov/36603033 - Stempinski PR, Gerbig GR, Greengo SD and Casadevall A (2023). Last but not yeast-The many forms of Cryptococcus neoformans. PLoS Pathog. 19(1):e1011048.
https://pubmed.ncbi.nlm.nih.gov/36602969 - Mattoon ER, Cordero RJB and Casadevall A (2023). Melaninization Reduces Cryptococcus neoformans Susceptibility to Mechanical Stress. mSphere. 8(1):e0059122.
https://pubmed.ncbi.nlm.nih.gov/36602315 - Smith DFQ, Dragotakes Q, Kulkarni M, Hardwick JM and Casadevall A (2022). Galleria mellonella immune melanization is fungicidal during infection. Commun Biol. 5(1):1364.
https://pubmed.ncbi.nlm.nih.gov/36510005 - Smith DFQ, Mudrak NJ, Zamith-Miranda D, Honorato L, Nimrichter L, Chrissian C, Smith B, Gerfen G, Stark RE, Nosanchuk JD and Casadevall A (2022). Melanization of Candida auris Is Associated with Alteration of Extracellular pH. J Fungi(Basel). 8(10):1068.
https://pubmed.ncbi.nlm.nih.gov/36294632 - Jung EH, Park YD, Dragotakes Q, Ramirez LS, Smith DQ, Reis FCG, Dziedzic A, Rodrigues ML, Baker RP, Williamson PR, Jedlicka A, Casadevall A and Coelho C (2022). Cryptococcus neoformans releases proteins during intracellular residence that affect the outcome of the fungal-macrophage interaction. Microlife. 3:uqac015.
https://pubmed.ncbi.nlm.nih.gov/36247839 - Stempinski PR, Smith DFQ and Casadevall A (2022). Cryptococcus neoformans Virulence Assay Using a Galleria mellonella Larvae Model System. Bio Protoc. 12(15):e4480.
https://pubmed.ncbi.nlm.nih.gov/36082366 - Smith DFQ and Casadevall A (2022). Disaster Microbiology-a New Field of Study. mBio. 13(4):e0168022.
https://pubmed.ncbi.nlm.nih.gov/35920557 - Cordero RJB, Dragotakes Q, Friello PJ and Casadevall A (2022). Melanin protects Cryptococcus neoformans from spaceflight effects. Environ Microbiol Rep. 14(4):679-685.
https://pubmed.ncbi.nlm.nih.gov/35852045 - Dragotakes Q, Jacobs E, Ramirez LS, Yoon OI, Perez-Stable C, Eden H, Pagnotta J, Vij R, Bergman A, D'Alessio F and Casadevall A (2022). Bet-hedging antimicrobial strategies in macrophage phagosome acidification drive the dynamics of Cryptococcus neoformans intracellular escape mechanisms. PLoS Pathog. 18(7):e1010697.
https://pubmed.ncbi.nlm.nih.gov/35816543 - Wear MP, Hargett AA, Kelly JE, McConnell SA, Crawford CJ, Freedberg DI, Stark RE and Casadevall A (2022). Lyophilization induces physicochemical alterations in cryptococcal exopolysaccharide. Carbohydr Polym. 291:119547.
https://pubmed.ncbi.nlm.nih.gov/35698377 - Liporagi Lopes LC, Korangath P, Dos Santos SR Jr, Gabrielson KL, Ivkov R and Casadevall A (2022). Bionized Nanoferrite Particles Alter the Course of Experimental Cryptococcus neoformans Pneumonia. Antimicrob Agents Chemother. 66(4):e0239921.
https://pubmed.ncbi.nlm.nih.gov/35293784 - Wear MP, Jacobs E, Wang S, McConnell SA, Bowen A, Strother C, Cordero RJB, Crawford CJ and Casadevall A (2022). Cryptococcus neoformans capsule regrowth experiments reveal dynamics of enlargement and architecture. J Biol Chem. 298(4):101769.
https://pubmed.ncbi.nlm.nih.gov/35218774 - Baker RP, Chrissian C, Stark RE and Casadevall A (2022). Cryptococcus neoformans melanization incorporates multiple catecholamines to produce polytypic melanin. J Biol Chem. 298(1):101519.
https://pubmed.ncbi.nlm.nih.gov/34942148 - Wang Y, Wear M, Kohli G, Vij R, Giamberardino C, Shah A, Toffaletti DL, Yu CA, Perfect JR, Casadevall A and Xue C (2021). Inositol Metabolism Regulates Capsule Structure and Virulence in the Human Pathogen Cryptococcus neoformans. mBio. 12(6):e0279021.
https://pubmed.ncbi.nlm.nih.gov/34724824 - Smith DFQ, Camacho E, Thakur R, Barron AJ, Dong Y, Dimopoulos G, Broderick NA and Casadevall A (2021). Glyphosate inhibits melanization and increases susceptibility to infection in insects. PLoS Biol. 19(5):e3001182.
https://pubmed.ncbi.nlm.nih.gov/33979323 - Fu MS, Liporagi-Lopes LC, Dos Santos SR Júnior, Tenor JL, Perfect JR, Cuomo CA and Casadevall A (2021). Amoeba Predation of Cryptococcus neoformans Results in Pleiotropic Changes to Traits Associated with Virulence. mBio. 12(2):e00567-21.
https://pubmed.ncbi.nlm.nih.gov/33906924 - Smith DFQ and Casadevall A (2021). Fungal immunity and pathogenesis in mammals versus the invertebrate model organism Galleria mellonella. Pathog Dis. 79(3):ftab013.
https://pubmed.ncbi.nlm.nih.gov/33544836 - Crawford CJ, Wear MP, Smith DFQ, d'Errico C, McConnell SA, Casadevall A and Oscarson S (2021). A glycan FRET assay for detection and characterization of catalytic antibodies to the Cryptococcus neoformans capsule. Proc Natl Acad Sci U S A. 118(5):e2016198118.
https://pubmed.ncbi.nlm.nih.gov/33514659 - Chrissian C, Lin CP, Camacho E, Casadevall A, Neiman AM and Stark RE (2020). Unconventional Constituents and Shared Molecular Architecture of the Melanized Cell Wall of C. neoformans and Spore Wall of S. cerevisiae. J Fungi (Basel). 6(4):329.
https://pubmed.ncbi.nlm.nih.gov/33271921