Departmental Affiliations
Center & Institute Affiliations
Keri N Althoff, PhD '08, MPH '05, uses large-scale longitudinal data to answer otherwise unanswerable questions and improve health, particularly for populations underrepresented in research.
Contact Info
Research Interests
HIV; AIDS; aging; kidney disease; liver disease; cardiovascular disease; cancer; hypertension; diabetes; influenza; quality of care; HIV Care Continuum; United States; health disparities; study design; big data; epidemiology
Experiences & Accomplishments
I use large-scale longitudinal data to answer otherwise unanswerable questions and improve health, particularly for populations under-represented in research. I have developed best practices for research collaborations, addressing bias in harmonized individual-level data collected using unique (not single) study protocols, and detailed strength and pitfalls of nested longitudinal study design in databases derived from electronic health records. I have translated these longitudinal cohort collaboration methods to nested studies in the Environmental influences on Child Health Outcomes [ECHO] study, and to produce empirical evidence to guide COVID-19 vaccination recommendations in people with HIV by establishing the Corona-Infectious-Virus Epidemiology Team (CIVETs) collaboration of cohorts. Utilizing my longitudinal study design expertise, I oversee the data management and analyses for the first cohort of transgender women to assess HIV incidence (the LITE/ENCORE study) and the Design Working Group for the HEALthy Brain and Child Development Study.
I have gained content expertise in aging with human immunodeficiency virus (HIV) infection. I estimate the impact of HIV-related and non-HIV-related risk factors on comorbidities to determine appropriate interventions for sub-groups. I forecast comorbidities and multimorbidity in 15 sub-groups of people with HIV using an agent-based simulation model I developed levering the rich longitudinal NA-ACCORD data. I think critically of the appropriate comparison groups for non-AIDS-related comorbidities in adults aging with HIV.
I have also gained content expertise in monitoring the quality of HIV care in the United States and progress towards the goals of the US National HIV/AIDS Strategy and Ending the HIV Epidemic initiative. By creating benchmarks and annual monitoring of progress towards national goals, and quantifying health disparities by demographic and geographic characteristics, I elucidate progress on the Strategy’s goals, including among important sub-groups. Finally, I am focused on extending the HIV Care Continuum to include indicators that are meaningful in the decades people live with HIV.
Importantly, I translate my research findings to scientific and non-scientific communities. Given the rise in distrust in scientists and public health professionals, my goal when communicating with lay audience is to lead with listening so that my communication is helpful to their daily lives and decision-making and helps, in whatever small way, to restore trust in scientists. I am also focused on developing tools to translate my research finings to policy and program decision-makers who could use the findings to improve health.
Honors & Awards
2022-2023 Bloomberg School of Public Health’s Faculty Leadership Program
2021 NIH Office of the Director’s Award for the Seroprevalence study in All of Us Research Program participants
2020 “Overall Best Paper” for 2020 from the American Journal of Epidemiology, American College of Epidemiology
2020 Bloomberg American Health Initiative COVID-19 Impact Award, Johns Hopkins Bloomberg School of Public Health
2018 Johns Hopkins University Catalyst Award
2018-2019 Johns Hopkins University School of Medicine Leadership Program for Women Faculty
2016 Editor’s Choice for: Buchacz K, Lau B, Jing Y, et al. Incidence of AIDS-Defining Opportunistic Infections in a Multicohort Analysis of HIV-infected Persons in the United States and Canada, 2000-2015. Journal of Infectious Diseases 2016; 214:862-872. doi: 10.1093/infdis/jiw085
2012 Editor’s Choice for: Silverberg MJ, Lau B, Justice AC, et al. Risk of anal cancer in HIV-infected and HIV-uninfected individuals in North America. Clin Infect Dis 2012;54:1026-1034
2011 Elected to the Delta Omega Honorary Public Health Society, Alpha Chapter, Johns Hopkins Boomberg School of Public Health
2007 The Dorothy and Arthur Samet Award for outstanding service to the department and community, Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University
Select Publications
Select publications:
Althoff KN, Stewart C, Humes E, Gerace L, Boyd C, Gebo K, Justice AC, Hyle EP, Coburn SB, Lang R, Silverberg MJ, Horberg MA, Lima VD, Gill MJ, Karris M, Rebeiro PF, Thorne J, Rich AJ, Crane H, Kitahata M Rubtsova A, Wong C, Leng S, Marconi VC, D’Souza G, Kim HN, Napravnik S, McGinnis K, Kirk GD, Sterling TR, More RD, Kasaie P. The forecasted prevalence of comorbidities and multimorbidity in people with HIV in the United States through the year 2030: A modeling study. PLOS Medicine. 2024 Jan 20;24(1):243. doi: 10.1371/journal.pmed.1004325. PMID: 38215160. PubMed Central PMCID: PM10833859.
Lang R, Humes E, Hogan B, Lee J, D'Agostino R, Massaro J, Kim A, Meigs JB, Borowsky L, He W, Lyass A, Cheng D, Kim HN, Klein MB, Cachay ER, Bosch RJ, Gill MJ, Silverberg MJ, Thorne JE, McGinnis K, Horberg MA, Sterling TR, Triant VA, Althoff KN. Evaluating the Cardiovascular Risk in an Aging Population of People With HIV: The Impact of Hepatitis C Virus Coinfection. J Am Heart Assoc. 2022 Oct 4;11(19):e026473. doi: 10.1161/JAHA.122.026473. Epub 2022 Sep 21. PubMed PMID: 36129038; PubMed Central PMCID: PMC9673707.
Coburn SB, Humes E, Lang R, Stewart C, Hogan BC, Gebo KA, Napravnik S, Edwards JK, Browne LE, Park LS, Justice AC, Gordon KS, Horberg MA, Certa JM, Watson E, Jefferson CR, Silverberg MJ, Skarbinski J, Leyden WA, Williams CF, Althoff KN. Analysis of Postvaccination Breakthrough COVID-19 Infections Among Adults With HIV in the United States. JAMA Netw Open. 2022 Jun 1;5(6):e2215934. doi: 10.1001/jamanetworkopen.2022.15934. PubMed PMID: 35671054; PubMed Central PMCID: PMC9175076.
Justice AC, Goetz MB, Stewart CN, Hogan BC, Humes E, Luz PM, Castilho JL, Nash D, Brazier E, Musick B, Yiannoutsos C, Malateste K, Jaquet A, Cornell M, Shamu T, Rajasuriar R, Jiamsakul A, Althoff KN. Delayed presentation of HIV among older individuals: a growing problem. Lancet HIV. 2022 Apr;9(4):e269-e280. doi: 10.1016/S2352-3018(22)00003-0. PubMed PMID: 35218732; PubMed Central PMCID: PMC9128643.
Althoff KN, Schlueter DJ, Anton-Culver H, Cherry J, Denny JC, Thomsen I, Karlson EW, Havers FP, Cicek MS, Thibodeau SN, Pinto LA, Lowy D, Malin BA, Ohno-Machado L, Williams C, Goldstein D, Kouame A, Ramirez A, Roman A, Sharpless NE, Gebo KA, Schully SD. Antibodies to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in All of Us Research Program Participants, 2 January to 18 March 2020. Clin Infect Dis. 2022 Mar 1;74(4):584-590. doi: 10.1093/cid/ciab519. PubMed PMID: 34128970; PubMed Central PMCID: PMC8384413.
Kasaie P, Stewart C, Humes E, Gerace L, Zhang J, Silverberg MJ, Horberg MA, Rebeiro PF, Hyle EP, Lima VD, Wong C, Gill MJ, Gebo K, Moore R, Kitahata MM, Althoff KN. Projecting the age-distribution of men who have sex with men receiving HIV treatment in the United States. Ann Epidemiol. 2022 Jan;65:46-55. doi: 10.1016/j.annepidem.2021.08.021. PubMed PMID: 34627998; PubMed Central PMCID: PMC8859821.